Search results for "Intracellular transport"
showing 3 items of 3 documents
Direct interaction of the Usher syndrome 1G protein SANS and myomegalin in the retina
2011
Contains fulltext : 96822.pdf (Publisher’s version ) (Closed access) The human Usher syndrome (USH) is the most frequent cause of combined hereditary deaf-blindness. USH is genetically heterogeneous with at least 11 chromosomal loci assigned to 3 clinical types, USH1-3. We have previously demonstrated that all USH1 and 2 proteins in the eye and the inner ear are organized into protein networks by scaffold proteins. This has contributed essentially to our current understanding of the function of USH proteins and explains why defects in proteins of different families cause very similar phenotypes. We have previously shown that the USH1G protein SANS (scaffold protein containing ankyrin repeat…
Golgi Fragmentation in Neurodegenerative Diseases: Is There a Common Cause?
2019
In most mammalian cells, the Golgi complex forms a continuous ribbon. In neurodegenerative diseases, the Golgi ribbon of a specific group of neurons is typically broken into isolated elements, a very early event which happens before clinical and other pathological symptoms become evident. It is not known whether this phenomenon is caused by mechanisms associated with cell death or if, conversely, it triggers apoptosis. When the phenomenon was studied in diseases such as Parkinson’s and Alzheimer’s or amyotrophic lateral sclerosis, it was attributed to a variety of causes, including the presence of cytoplasmatic protein aggregates, malfunctioning of intracellular traffic and/or alterations i…
Modeling of intracellular transport in realistic cell geometries
2018
The transport of molecules inside cells is a complex process, the characterization of which is important to gain full understanding of cellular processes. Understanding of intracellular transport is also important for medical applications, for example when analyzing transport of medicine inside cells. The intracellular environment is very complex, and at least the most crucial parts of this complexity must be accounted for to solve transport problems in cells. In this thesis the results of studies in modeling intracellular transport are presented. The aim of the work was to model intracellular transport of proteins and viral capsids in realistic cell environments. To this end, microscopic m…